Genetic Polymorphisms Associated with Methylphenidate

COMMENT Attention Deficit Hyperactivity Disorder is one of the most common psychiatric diagnoses of childhood, and many formulations of methylphenidate (e.g., Metadate CD, Focalin and Focalin XR, Ritalin LA, Concerta) are utilized for its treatment. Clinicians have puzzled why some individuals seem to be usually sensitive to methylphenidate products while others require high dosages. It [...]

Herb-Drug Interactions

COMMENT: H. canadensis (goldenseal or Golden Seal, a perennial  of the buttercup family), otherwise known as: yellow root, orange root, puccoon, ground raspberry or  wild curcuma has been an important herbal medicine since settlers learned of it from Native Americans who used it for many purposes including:for mucosal infections, for colds or flu, for dyspepsia [...]

Bush Signs Genetic Nondiscrimination Bill Into Law

President George Bush signed the Genetic Information Nondiscrimination Act into law this afternoon, making it illegal to discriminate on matters of employment and health insurance in the US based on genetic information. Many Americans cited concern about the misuse of their genetic information as the reason they did not order genetic tests that could improve [...]

How Genomic Medicine Is Changing the Management of Breast & Ovarian Cancer

Our friends at Helix Health, a medical practice with expertise in genomic medicine are hosting a free 90-minute webcast this Wednesday, May 21, 2008 from 1:00-2:30 PM EDT on: How Genomic Medicine Is Changing the Management of Breast & Ovarian Cancer.  To register, point your browser here: http://event.netbriefings.com/event/helixhealth/register.html. Join NPR’s David Ewing Duncan, author Jessica [...]

The role of hepatic transporters in drug elimination

COMMENT: This article helps develop a picture of hepatic cells transporters, both the ABC and the SLC superfamilies and of the drugs they transport. ABC effluxers line the bile canniculi and export drugs into the bile while the SLCs are poised on the basolateral or blood border and influx drugs, both anionic and cationic. Phase [...]

OATP Knock Out Murine Model

COMMENT: The mutant in vivo mouse model or the so-called “knock out” (ko) mouse in which a single gene is deleted or disrupted is increasingly used for the exploration of drug interactions. In the case of the OATP transporters, the so-called SLCO or SLC21 subfamily, the mouse has a single hepatic SLCO transporter, the SLC01B2 [...]

Follow

Get every new post delivered to your Inbox.