COMMENT: The mutant in vivo mouse model or the so-called “knock out” (ko) mouse in which a single gene is deleted or disrupted is increasingly used for the exploration of drug interactions. In the case of the OATP transporters, the so-called SLCO or SLC21 subfamily, the mouse has a single hepatic SLCO transporter, the SLC01B2 [...]
Filed under: Cytochrome P450, Drug Interactions, Personalized Medicine, Pharmacogenetics | Tagged: Drug Interactions, drug metabolism, inducer, inhibitor, OATP, pravastatinsubstrate, rifampin, SLC, transporters | Leave a Comment »
