COMMENT: The fact that desipramine levels were doubled with the addition of bupropion was a surprising clinical event because bupropion’s Ki is so high that it was though not possible for it to significntly inhibit CYP2D6 (IC50 is more than 50uM). In this in vitro study, it is shown that the actual culprits (perpetrators) of [...]
Filed under: Cytochrome P450, Drug Interactions, Personalized Medicine | Tagged: Bupropion, CYP, CYP2D6, Cytochrome P450, Desipramine, Drug Interactions, Drug-Drug Interaction, Personalized Medicine | Leave a Comment »
