Harmsen S, Koster A, Beijnen JH, Schellens JH, Meijerman I.Utrecht University. Since cytochrome P450 3A4 (CYP3A4) is responsible for the biotransformation of over 50% of all clinically used drugs, induction results in an increased clearance of many concomitantly administered drugs, thereby decreasing treatment efficacy or, in the case of pro-drugs, lead to severe intoxications. CYP3A4 [...]
Filed under: Cytochrome P450, Personalized Medicine | Tagged: CYP3A, Cytochrome, INDUCTION | Leave a Comment »
