COMMENT: At first, montelukast was believed to be an inhibitor of multiple CYPs because of invitro evidence. In 2005, had it been shown that it was a selective invitro CYP2C8 inhibitor (PMID 15608135). However, the study below shows unequivocally that it is not a CYP2C8 inhibitor in vivo. ABSTRACT: Br J Clin Pharmacol. 2007 Mar;63(3):339-45. [...]
Filed under: Cytochrome P450, Personalized Medicine | Tagged: CYP2C8, Cytochrome P450, rosiglitazone | Leave a Comment »
