COMMENT: This pair of articles highlights the importance of not relying on invitro data in predicting drug interactions. In the Kim article, pomegranate juice showed invitro inhibition of CYP3A4 that was not supported in an invivo study by Farkas. ABSTRACTS:</font>Farkas D, Oleson LE, Zhao Y, Harmatz JS, Zinny MA, Court MH, Greenblatt DJ.Pomegranate juice does [...]
Filed under: Cytochrome P450, Drug Interactions, Personalized Medicine | Tagged: 3A4, adrs, CYP3A, cytochromes, Drug Interactions | Leave a Comment »
