Inhibition on human liver cytochrome P450 3A4 by constituents of fennel

Dr. Oesterheld’s Comment: Although clinicians may be well aware of the potential of grapefruit juice to be an inhibitor of CYP3A4, only a few may be aware of the possibility of other CYP-based food- drug interactions.In this study, fennel, an herb and alternate drug is shown to be a modest CYP3A4 inhibitor. Since its inhibition [...]

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