pubmed: Cytochrome P450 Huma… pubmed: Pharmacogenetics Hum… pubmed: Drug Interactions Hu…Comment from Dr. Oesterheld: Tramadol is a pro-drug and is metabolized to its active metabolite O-desmethyltramadol via CYP2D6. Although there have been case reports of individuals who were ultrarapid metabolizers of CYP2D6 who had adverse drug reactions to this drug, there has been no clinical study that supports this outcome. The authors rightly state that [...]
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Comment from Dr. Oesterheld: Cinacalcet is a calcium- reducing drug commonly used in patients with chromic renal failure/dialysis. Although it was known that cinacalcet is a CYP2D6 inhibitor, and desipramine levels were increased when co-administered with this drug, the Ki of cinacalcet was not known to be similar to quinidine and thus amongst the most [...]
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Comment from Dr. Oesterheld: This article shows how sophisticated clinical studies have become, this study shows that genetic variations of ABCB1 and CYP2C19 can increase lansoprazole concentration and secondarily, decrease the absorption of mycophenolic acid. So this drug interaction is based in genetic variation and changes in absorption. Ther Drug Monit. 2008 Feb;30(1):46-51. Influence of [...]
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