Worshiping at the Altar of Randomized Trials

AHRQ’s Evidence Report on Depression, CYP450 Testing for Adults Treated with SSRIs concluded “There is a paucity of good-quality data addressing the questions of whether testing for CYP450 polymorphisms in adults entering SSRI treatment for non-psychotic depression leads to improvement in outcomes, or whether testing results are useful in medical, personal, or public health decisionmaking.” [...]

Cytochrome P450 testing for better psychiatric care

J Psychosoc Nurs Ment Health Serv. 2007 Oct;45(10):15-8. Link: Cytochrome P450 testing for better psychiatric care. Pestka EL, Hale AM, Johnson BL, Lee JL, Poppe KA. Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. pestka.elizabeth@mayo.edu Genotyping for CYP2D6 and CYP2C19 variations is emerging as a potentially useful clinical tool to help mental [...]

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