How Many Deaths Will it Take?

Posted on November 29, 2007 by DNADiva

I read an article recently by Dr. Mrazek at the Mayo Clinic entitled “How Many Deaths Will it Take.” The article pointed out the number of deaths from adverse drug reactions and that widespread adoption of pharmacogenetic testing would reduce this number. Yesterday, Dr. Mrazek’s statement came closer to home. I received an e-mail from Roman [...]

Filed under: Cytochrome P450, Personalized Medicine, Pharmacogenetics | Tagged: , , , , , , | 1 Comment »

Could Grapefruit Juice Cut Drug Costs?

Posted on November 27, 2007 by DNADiva

Posted by Jacob Goldstein, WSJ An enzyme that lives in the gut, charmingly named CYP3A4, breaks down drugs before they enter the bloodstream. So people with lots of CYP3A4 may have less medicine enter their blood than people who don’t have so much. Enter the grapefruit. Grapefruit juice has a compound that temporarily gets rid [...]

Filed under: Cytochrome P450, Drug Interactions | Tagged: , | Leave a Comment »

A Simple DNA Test Helps Physicians Tailor Breast Cancer Treatment- So Why is it Underutilized?

Posted on November 26, 2007 by DNADiva

If you go to PubMed and enter in Tamoxifen and 2D6, the research speaks clearly. A good synopisis from the Genelex Fall newsletter is included below. The question is why is this testing still rarely ordered? What are your thoughts? According to the American Cancer Society, one in eight women in the United States will [...]

Filed under: Cytochrome P450, Personalized Medicine, Pharmacogenetics | Tagged: , , , , | 2 Comments »

Genetic Guidance of Warfarin Dosing Shows Promise from Heartwire – Sue Hughes

Posted on November 15, 2007 by DNADiva

November 7, 2007 (Orlando, FL) – Using genetic tests as well as clinical factors improved the accuracy and efficiency of warfarin dose initiation, but the primary end point of a reduction in out-of- range INRs was not significantly changed in the overall population in the Couma-Gen study [1]. Subgroup analysis suggested, however, that pharmacogenetic guidance [...]

Filed under: Cytochrome P450, Personalized Medicine, Pharmacogenetics | Tagged: , , , , , | 2 Comments »

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