pubmed: Cytochrome P450 Huma… pubmed: Pharmacogenetics Hum… pubmed: Drug Interactions Hu…Smith, G. Stanley, L.A. Sim, E. Strange, R.C. Wolf C. R. Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee. The vast majority of cancers arise as a consequence of exposure to environmental agents that are toxic or mutagenic. In response to this, all higher organisms have evolved complex mechanisms by which they can protect [...]
Filed under: Cytochrome P450 | Tagged: GSTs, NATs | Leave a Comment »
J Biochem Mol Biol. 2007 May 31;40(3):448-52 Authors: Lee SY, Lee ST, Kim JW We examined the contribution of CYP2C9 and CYP2C19 genotypes and drug interactions to the phenytoin metabolism among 97 Korean epileptic patients to determine if pharmacogenetic testing could be utilized in routine clinical practice. The CYP2C9 polymorphism is a wellknown major genetic [...]
Filed under: Pharmacogenetics | Tagged: CYP219, CYP2C9, Pharmacogenetics | 1 Comment »
Med Hypotheses. 2006;67(5):1090-4 Authors: Alisky JM, Chertkova EL, Iczkowski KA BACKGROUND Chloroquine and mefloquine used for prophylaxis and treatment of malaria sometimes causes severe mental status changes, through mechanisms that are poorly understood. PRESENTATION OF THE HYPOTHESIS Psychosis is caused by interactions with other drugs or by pharmacogenetic vulnerabilities that cause heightened responses to chloroquine [...]
Filed under: Drug Interactions | Tagged: Drug Interactions, psychosis | 1 Comment »
Mol Diagn Ther. 2007;11(2):123-8 Authors: Beinema MJ, de Jong PH, Salden HJ, van Wijnen M, van der Meer J, Brouwers JR OBJECTIVE To determine the influence of NSAIDs on the international normalized ratio (INR) in patients with cytochrome P450 (CYP)-2C9 enzyme variants starting acenocoumarol (an oral coumarin) therapy during the first 7 days after total [...]
Filed under: Personalized Medicine | Tagged: Coumarin, CYP2C9 | Leave a Comment »
